Endocrine Abstracts

Introduction: Parathyroid adenoma is the commonest cause of primary hyperparathyroidism, but 10% of these adenomas can be ectopic, leading to persistent and recurrent hypercalcaemia.Case: We present a case of 82 years old man was admitted in June 2011 with increasesd confusion, slurred speech, poor balance (ataxia). He had no features of sepsis and no other focal neurology. His past medical history included constipation, dry eyes. He was on Aspirin, hypr...

Background: Histoplasmosis is an opportunistic fungal infection that commonly affects immunocompromised individuals. Histoplasmosis may be asymptomatic or may present with progressive systemic manifestations (pulmonary or disseminated). We present a case of a 76 year old immunocompetent man presented to hospital with 8 weeks history of general malaise and lethargy, intermittent night sweats, a productive cough, weight loss of 2.5 stones in two months and low grade fever. He ha...

Tuberculosis affecting the pituitary gland is a rare phenomenon and is usually the result of haematological spread from another site. Only 0.9% of cases of TB in the UK, in 2012, showed any CNS involvement, excluding meningitis1. The clinical presentation of pituitary TB, range of hormonal dysfunction and radiological features can vary, making it hard to identify the condition. We report two clinical cases seen in our department.Case 1: A 48-y...

Introduction: Older patients with diabetes mellitus often have concomitant comorbidities and physical disabilities which may lead to poor quality of life. The present diabetic guidelines available to clinicians in their practice suggest aggressive and meticulous diabetic control for target HbA1c (<7%). This is aimed at delaying or preventing complications. Such practice may predipose majority of older patients to experience recurrent hypoglycaemic epidodes and therefore co...

Background: Patients with thyroid abnormalities often also suffer with anxiety and depression. Our objectives in this study was to investigate prospectively the effect of thyroid dysfunction per se on quality of life and levels of depression and anxiety.Methods: A total of 102 patients who were referred to thyroid clinic were enrolled in the study in consecutive order. Enrollment criteria comprised patient aged 20–60 with no major life events, previ...

Background: Haemoglobinopathies are inherited disorders of haemoglobin that predispose to endocrinopathies. The common ones include growth delay, hypogonadism and subsequent osteopaenia. Less commonly seen are diabetes mellitus, thyroid and adrenal disorders. Aetiology is multifactorial and includes tissue hypoxia, chronic anaemia, iron overload, high energy demand, genetic influence and malnourishment. We present three case reports which illustrate the endocrinopathies amongs...

Background: Managing mental health patients with Diabetes Mellitus can be challenging. Patients with mental health problems are poorly compliant with both antipsychotic and diabetes treatment. Literature has suggested that some psychiatric illnesses can be independent risk factors for diabetes. Furthermore, diabetic patients have a higher incidence of psychiatric disorders. There is a causal relationship between newer antipsychotic medications and metabolic abnormalities.<...

Background: SIADH is a condition characterized by excessive ADH secretion from the posterior pituitary in the absence of triggers like high plasma osmolality and low blood volume or low blood pressure. This leads to excessive and unwanted water retention and increase in the total body water content, though the plasma sodium levels are normal.Case: An 89 y/o gentleman was admitted after he sustained a fall at his home and was diagnosed with right neck of ...

Background: Lung cancers are one of the leading causes of death worldwide which has resulted in an increase in immunotherapy, particularly immune checkpoint inhibitors (ICIs). Recent studies have shown induced endocrinopathies secondary to ICIs as a result of pancreatic beta cells, thyroid, and pituitary dysfunction.Aim: We aim to present an interesting case of Type 1 Diabetes mellitus secondary to immunotherapy. Pembrolizumab is used to treat melanoma, ...

Objective: We present a case of hypertriglyceridemia induced acute pancreatitis (HTG-AP) and concurrent diabetic ketoacidosis (DKA) as a first presentation of Diabetes Mellitus in an adult patient. This uncommon triad has been previously described in the literature, however, it is rare to be observed in a previously undiagnosed patient with diabetes. The purpose of this poster is to describe the potential mechanisms for this and discuss management strategies.<p class="abst...